Science

Carbon Dioxide Water Bathing Enhances Myogenin but Not MyoD Protein Expression after Skeletal Muscle Injury

Abstract [Purpose] We reported that carbon dioxide (CO2) water bathing accelerates skeletal muscle regeneration; however, the underlying mechanism was unclear. MyoD and myogenin play roles in muscle regeneration, and the purpose of this study was to determine changes in MyoD and myogenin caused by CO2 water bathing after injury. [Subjects] Sixteen female Wistar rats (n …

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Transcutaneous Carbon Dioxide Improves Contractures After Spinal Cord Injury in Rats

Abstract Background: Joint contractures are a major complication in patients with spinal cord injuries. Positioning, stretching, and physical therapy are advocated to prevent and treat contractures; however, many patients still develop them. Joint motion (exercise) is crucial to correct contractures. Transcutaneous carbon dioxide (CO2) therapy was developed recently, and its effect is similar to that of …

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Transcutaneous carbon dioxide application accelerates muscle injury repair in rat models

Abstract Purpose: Skeletal muscle injuries are commonly observed in sports and traumatology medicine. Previously, we demonstrated that transcutaneous application of carbon dioxide (CO2) to lower limbs increased the number of muscle mitochondria and promoted muscle endurance. Therefore, we aimed to investigate whether transcutaneous CO2 application could enhance recovery from muscle injury. Methods: Tibialis anterior muscle damage was induced …

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The effect of transcutaneous application of carbon dioxide (CO2) on skeletal muscle

Abstract In Europe, carbon dioxide therapy has been used for cardiac disease and skin problems for a long time. However there have been few reports investigating the effects of carbon dioxide therapy on skeletal muscle. Peroxisome proliferators-activated receptor (PPAR)-gamma coactivator-1 (PGC-1α) is up-regulated as a result of exercise and mediates known responses to exercise, such …

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Is carboxytherapy a good alternative method in the removal of various skin defects?

Abstract Carbon dioxide is a physiologic compound present in our body, mainly as a result of cellular metabolism. The frequency of carboxytherapy use by dermatologists and cosmetologists increased significantly in the second half of the 20th century due to the fact that it improves blood circulation within skin tissues. This article focuses on the use …

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Subcutaneous Carboxytherapy Injection for Aesthetic Improvement of Scars

A 60-year-old woman presented with a chief complaint of scarring along the sites of a submental incision and a right preauricular incision that had been made 5 years earlier during a rhytidectomy procedure. Examination revealed tethering, hypertrophy, and erythema of the submental incision (Figure 1, A) and widening of the preauricular incision (Figure 2, A). …

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Carbon dioxide therapy: effects on skin irregularity and its use as a complement to liposuction

Abstract For a successful conventional or superficial liposuction, it is necessary to consider the competence of the surgeon who is to administer the procedure necessary for this type of surgery as well as the physical and psychological evaluation of the determined patient. A poor result often is related to the persistence of adipose tissue irregularity …

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Clinical Prospective Study on the Use of Subcutaneous Carboxytherapy in the Treatment of Diabetic Foot Ulcer

Abstract Diabetic foot foot ulcer (DFU) is a serious complication of diabetes mellitus, and possibly the major morbidity of the diabetic foot. It is the most common foot injury in diabetic patients and can lead to lower-extremity amputation. Management of DFU requires a systematic knowledge of the major risk factors for amputation, frequent routine evaluation, …

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Effect of transcutaneous application of gaseous carbon dioxide on cutaneous microcirculation

Abstract Background: The inefficient healing of chronic wounds is a result of poor blood perfusion at the wound and surrounding tissues. Artificially applied carbon dioxide (CO2) has the potential to improve the perfusion and oxygenation of tissues, hence is useful for the healing of chronic wounds. Objective: The aim of the present study was to determine the …

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